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Kochanova, N.Y., M.A. Abad, P. Vizjak, A.A. Jeyaprakash, W.C. Earnshaw and G. Kustatscher. (2023) ChromatoShiny: an interactive R/Shiny App for plotting chromatography profiles. Wellcome Open Res. 8:332; PMID: 37692131; PMCID: PMC10483177; FREE ARTICLE
Liskovykh, M., N.S. Petrov, V.N. Noskov, H. Masumoto, W.C. Earnshaw, D. Schlessinger, S.A. Shabalina, V. Larionov & N. Kouprina. (2023). Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli. Mol. Cell. Life Sci. 80:121; PMID: 3704302; PMCID:10097779; FREE ARTICLE
Stamatiou, K., A. Chmielewska, S. Ohta, W.C. Earnshaw & Paola Vagnarelli (2023). CCDC86/Cyclon is a novel Ki-67 interacting protein important for cell division. J. CELL SCI. 136: jcs260391. FREE ARTICLE
Okazaki, K., Nakano, M., Ohzeki, J. I., Otake, K., Kugou, K., Larionov, V., Earnshaw, W. C., & Masumoto, H. (2022). Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation. Cells, 11(9), 1378. FREE ARTICLE
Bouayad-Gervais, S., St-Cyr, D. J., Courcelles, M., Bonneil, É., Gohard, F. H., Thibault, P., Earnshaw, W. C., & Tyers, M. (2022). Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides. Peptide Science (Hoboken, N.J.), 114(3), e24254. FREE ARTICLE
Politi, V., Perini, G., Trazzi, S., Pliss, A., Raska, I., Earnshaw, W. C., & Valle, G. D. (2022). Expression of Concern: CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. Journal of Cell Science, 135(18), jcs260575. FREE ARTICLE
Samejima, I., Spanos, C., Samejima, K., Rappsilber, J., Kustatscher, G., & Earnshaw, W. C. (2022). Mapping the invisible chromatin transactions of prophase chromosome remodeling. Molecular Cell, 82(3), 696–708.e4. FREE ARTICLE
Gerbi, S. A., Palazzo, R. E., Earnshaw, W. C., & Schrader, W. T. (2021). William R. Brinkley: A giant in biomedical research and public policy. The Journal of Cell Biology, 220(10), e202106102. FREE ARTICLE
Paulson, J. R., Hudson, D. F., Cisneros-Soberanis, F., & Earnshaw, W. C. (2021). Mitotic chromosomes. Seminars in Cell & Developmental Biology, 117, 7–29. FREE ARTICLE
Remnant, L., Kochanova, N. Y., Reid, C., Cisneros-Soberanis, F., & Earnshaw, W. C. (2021). The intrinsically disorderly story of Ki-67. Open Biology, 11(8), 210120. FREE ARTICLE
Petrov, N., Lee, H. S., Liskovykh, M., Teulade-Fichou, M. P., Masumoto, H., Earnshaw, W. C., Pommier, Y., Larionov, V., & Kouprina, N. (2021). Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells. Oncotarget, 12(15), 1444–1456. FREE ARTICLE
Pesenti, E., M. Liskovykh, K. Okazaki, A. Mallozzi, C. Reid, M. A. Abad, A. A. Jeyaprakash, N. Kouprina, V. Larionov, H. Masumoto, W. C. Earnshaw. (2020). Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation. ACS Synth Biol. PMID: 33289546; DOI: 10.1021/acssynbio.0c00326. FREE ARTICLE
Boteva L., R.S. Nozawa, C. Naughton, K. Samejima, W.C. Earnshaw & N. Gilbert N. (2020). Common fragile sites are characterised by faulty condensin loading after replication stress. Cell Reports 32: 108177. PMID: 32966795; PMC7511797; DOI: 10.1016/j.celrep.2020.108177. FREE ARTICLE
Tsunematsu T., R. Arakaki, H. Kawai, J. Ruppert, K. Tsuneyama, N. Ishimaru, W.C. Earnshaw, M. Pagano & Y. Kudo (2020). APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit. J. Cell Sci. 133: jcs251314. PMID: 32934012; PMC7520452; DOI: 10.1242/jcs.251314. FREE ARTICLE
Otake, K. J. Ohzeki, N. Shono, K. Kugou, K. Okazaki, T. Nagase, H. Yamakawa, N. Kouprina, V. Larionov, H. Kimura, W.C. Earnshaw & H. Masumoto. (2020). CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly. J. Cell Sci. 133: jcs243303: PMID: 32661090; PMC7438015; DOI: 10.1242/jcs.243303. FREE ARTICLE
Martins, N. M. C., F. Cisneros-Soberanis, E. Pesenti, N. Y. Kochanova, W. Shang, T. Hori, T. Nagase, H. Kimura, V. Larionov, H. Masumoto, T. Fukagawa, W. C. Earnshaw. (2020). H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory. J. Cell Sci. PMID: 32576667; DOI: 10.1242/jcs.242610. FREE ARTICLE
Cuijpers S.A.G., E. Willemstein, J. G, Ruppert, D.M. van Elsland, W.C. Earnshaw & A.C.O. Vertegaal. (2020). Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner. J. Cell Sci. 133: jcs248591: PMID: 32591481; PMC7390632; DOI: 10.1242/jcs.248591. FREE ARTICLE
Abad, M. A., J. G. Ruppert, L. Buzuk, M. Wear, J. Zou, K. M. Webb, D. A. Kelly, P. Voigt, J. Rappsilber, W. C. Earnshaw and A. A. Jeyaprakash. (2019). Borealin-Nucleosome Interaction Secures Chromosome Association of the Chromosomal Passenger complex. J. Cell Biol. in press. PMID: 31570499; DOI: 10.1083/jcb.201905040. FREE ARTICLE
Papini, D., X. Fant, H. Ogawa, N. Desban, K. Samejima, O. Feizbakhsh, B. Askin, T. Ly, W.C. Earnshaw† & S. Ruchaud†. (2019). Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1. J. Cell Sci. 132: jcs234401 †equal corresponding authors. PMID: 31601613; DOI: 10.1242/jcs.234401. FREE ARTICLE
Liskovykh, M., N.V. Goncharov, N. Petrov, V. Aksenova, G. Pegoraro, L.L. Ozbun, W.C. Reinhold, S. Varma, M. Dasso, V. Kumeiko, H. Masumoto, W.C. Earnshaw, V. Larionov and N. Kouprina. (2019). A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission. Genome Res. 29:1719-1732 PMID: 31515286; PMC6771407; DOI: 10.1101/gr.254276.119. FREE ARTICLE
Remnant L., D.G. Booth, G. Vargiu, C. Spanos, A.R.W. Kerr, W.C. Earnshaw. (2019). In vitro BioID: Mapping the CENP-A Micro-Environment with high temporal and spatial resolution. Mol. Biol. Cell 30:1314-1325. PMID: 30892990; PMC6724601; DOI: 10.1091/mbc.E18-12-0799. FREE ARTICLE
Ohzeki, J., V. Larionov, W.C. Earnshaw & H. Masumoto. (2019). De novo formation and epigenetic maintenance of centromere chromatin. Curr. Opin. Cell Biol 58:15-25. PMID: 30654232; PMC6626702; DOI: 10.1016/j.ceb.2018.12.004. FREE ARTICLE
Rata, S. M.F. Suarez Peredo Rodriguez, S. Joseph, N. Peter, F.E. Iturra, F. Yang, A. Madzvamuse, J.G. Ruppert, K. Samejima, M. Platani, M. Alvarez-Fernandez, M. Malumbres, W.C. Earnshaw, B. Novak & H. Hochegger. (2018). Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells Curr Biol. 28: 3824–3832. PMID: 30449668; PMC6287978; DOI: 10.1016/j.cub.2018.09.059. See also: M.L. Goldberg, (2018) Cell Cycle: Abrogating Interphase/M Phase Bistability Curr. Biol. 28, R1335–R1355. FREE ARTICLE
Lee, H.S.*, M. Carmena*, M. Liskovykh, E. Peat, J.H. Kim, M. Oshimura, H. Masumoto, M.P. Teulade-Fichou, Y. Pommier, W.C. Earnshaw, V. Larionov & N. Kouprina. (2018). *equal first authors. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy. Cancer Res. 78: 8 6282-6296. PMID: 30166419; PMC6214708; DOI: 10.1158/0008-5472.CAN-18-0894. FREE ARTICLE
Kouprina N., N. Petrov, O. Molina, M. Liskovykh, E. Pesenti, J.I. Ohzeki, H. Masumoto, W.C. Earnshaw & V. Larionov. (2018). Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies. ACS Synth Biol. 7: 1974-1989. PMID: 30075081; PMC6154217; DOI: 10.1021/acssynbio.8b00230. FREE ARTICLE
Saldivar, J.C., S. Hamperl, M.J. Bocek, M. Chung, T.E. Bass, F. Cisneros-Soberanis, K. Samejima, L. Xie, J.R. Paulson, W.C. Earnshaw, D. Cortez, T. Meyer and K.A. Cimprich. (2018). An intrinsic S/G2 checkpoint enforced by ATR. Science 361:806-810. PMID: 30139873; PMC6365305; DOI: 10.1126/science.aap9346. (Faculty of 1000) FREE ARTICLE
Platani M., I. Samejima, K. Samejima, M.T. Kanemaki and W.C. Earnshaw. (2018). Seh1 targets GATOR2 and Nup153 to mitotic chromosomes J. Cell Science, 131: jcs213140. PMID: 29618633; PMC29618633; DOI: 10.1242/jcs.213140. See also: Linking mTOR signalling to mitosis – the role of Seh1. J Cell Sci 2018 131: e0901 FREE ARTICLE
Pesenti E., N. Kouprina, M. Liskovykh, J. Aurich-Costa, V. Larionov, H. Masumoto, W.C. Earnshaw† and O. Molina†. (2018). Generation of a synthetic human chromosome with two centromeric domains for advanced epigenetic engineering studies. ACS Synthetic Biology, 20: 1116-1130. †equal corresponding authors. PMID: 29565577; PMC: 5951608; DOI: 10.1021/acssynbio.8b00018. FREE ARTICLE
Combes G., H. Barysz, C. Garand, L. Gama Braga, I. Alharbi, P. Thebault, L. Murakami, D.P. Bryne, S. Stankovic, P.A. Eyers, V.M. Bolanos-Garcia, W.C. Earnshaw, J. Maciejowski, P.V. Jallepalli and S. Elowe. (2018). Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint. Curr Biol. 28: 872-883. PMID: 29502948; PMC5863767; DOI: 10.1016/j.cub.2018.02.002. FREE ARTICLE
Ladds M.J.G.W., I.M.M. van Leeuwen, C.J. Drummond, S. Chu, A.R. Healy, G. Popova, A.P. Fernández, T. Mollick, S. Darekar, S.K. Sedimbi, M. Nekulova, M.C.C. Sachweh, J. Campbell, M. Higgins, C. Tuck, M. Popa, M.M. Safont, P. Gelebar, Z. Fandalyuk, A.M. Thompson, R. Svensson, A.-L. Gustavsson, L. Johansson, K. Färnegårdh, U. Yngve, A. Saleh, M. Haraldsson, A.C.A. D’Hollander, M. Franco, Y. Zhao, M. Håkansson, B. Walse, K. Larsson, E.M. Peat, V. Pelechano, J. Lunec, B. Vojtesek, M. Carmena, W.C. Earnshaw, A.R. McCarthy, N.J. Westwood, M. Arsenian-Henriksson, D.P. Lane, R. Bhatia, E. McCormack and S. Laín (2018). A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. NATURE COMM. 9:1107. PMID: 29549331; PMC5856786; DOI: 10.1038/s41467-018-03441-3. FREE ARTICLE
Ruppert J.G., K. Samejima, M. Platani, O. Molina, H. Kimura, A.A. Jeyaprakash, S. Ohta and W.C. Earnshaw. (2018). HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry. EMBO J. 37, e97677. PMID: 29467217; PMC5852645; DOI: 0.15252/embj.201797677. FREE ARTICLE
Gibcus, J.H.*, K. Samejima*, A. Goloborodko*, I. Samejima, N. Naumova, J. Nuebler, M. Kanemaki, L. Xie, J.R. Paulson, W.C. Earnshaw†, L.A. Mirny†, J. Dekker†. (2018). A pathway for mitotic chromosome formation. Science 9:359. *equal first authors. †equal corresponding authors. PMID: 29348367; PMC5924687; DOI: 10.1126/science.aao6135. Co-communicating author, See also: Nat. Rev. Cell Biol. 19:139 A stairway to mitotic chromosome assembly (DOI: 10.1038/nrm.2018.13); See also: Quanta Magazine – https://www.quantamagazine.org/how-cells-pack-tangled-dna-into-neat-chromosomes-20180222/ (Faculty of 1000) FREE ARTICLE
Samejima K., D. Booth, H. Ogawa, J. Paulson, L. Xie, C. Watson, M. Platani, M.T. Kanemaki and W.C. Earnshaw. (2018). Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis. J. Cell Science, 131. pii: jcs210187. PMID: 29361541; PMC5868952; DOI: 10.1242/jcs.210187; FREE ARTICLE
Lee N.C.O, J.H. Kim, N. Petrov, H.S. Lee, H. Masumoto, W.C. Earnshaw, V. Larionov and N. Kouprina (2018). Method to assemble genomic DNA fragments or genes on Human Artificial Chromosome with regulated kinetochore using a multi-integrase system. ACS Synth Biol. 7:63-74. PMID: 28799737; PMC5778389; DOI: 10.1021/acssynbio.7b00209; FREE ARTICLE
Samejima I. & W.C. Earnshaw. (2018). Isolation of mitotic chromosomes from vertebrate cells and characterization of their proteome by mass spectrometry. Methods Cell Biol. 144: 329-348: PMID: 29804675; DOI: 10.1016/bs.mcb.2018.03.021. ARTICLE
Booth, D.G. and W.C. Earnshaw (2017) Ki-67 and the Chromosome Periphery Compartment in Mitosis. Trends Cell Biol. 27:906-916. PMID: 28838621; DOI: 10.1016/j.tcb.2017.08.001; ARTICLE
Molina, O., N. Kouprina, H. Masumoto, V. Larionov and W.C. Earnshaw (2017). Using human artificial chromosomes to study centromere assembly and function. Chromosoma 126:559-575. PMID: 28688039; DOI: 10.1007/s00412-017-0633-x; ARTICLE
Zhiteneva, A., J.J. Bonfiglio, A. Makarov, T. Colby, P. Vagnarelli, E.C. Schirmer, I. Matic and W.C Earnshaw. (2017). Mitotic post-translational modifications of histones promote chromatin compaction in vitro. Open Biol. 7, pii: 170076. PMID: 28903997; PMC5627050; DOI: 10.1098/rsob.170076; FREE ARTICLE
Spiller, F., B. Medina-Pritchard, M.A. Abad, M. Wear, O. Molina, W.C. Earnshaw and A.A. Jeyaprakashsh. (2017) Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition. EMBO Repts. 18: 894-905. PMID: 28377371; PMC5452045; DOI: 10.15252/embr.201643564; FREE ARTICLE
Vargiu, G., A.A. Makarov, J. Allan, T. Fukagawa, D.G. Booth and W.C. Earnshaw. (2017) Stepwise unfolding supports a subunit model for vertebrate kinetochores. Proc. Natl. Acad. Sci. U.S.A. 114: 3133-3138. PMID: 28265097; PMC5373359; DOI: 10.1073/pnas.1614145114; FREE ARTICLE
Montaño-Gutierrez, L.F., S. Ohta, G. Kustatscher, William C. Earnshaw, Juri Rappsilber. (2017). Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data. Mol. Biol. Cell. 15:2802-2818. PMID: 28057767; PMC5328625; DOI: 10.1091/mbc.E16-06-0370; FREE ARTICLE
Molina O., M. Carmena, I.E. Maudlin & William C. Earnshaw. (2016). PREditOR: a synthetic biology approach to removing heterochromatin from cells. Chromosome Res. 24:495-509. PMID: 27924426; PMC5167778; DOI: 10.1007/s10577-016-9539-3; FREE ARTICLE
Booth D.G., A.J. Beckett, O. Molina, I. Samejima, H. Masumoto, N. Kouprina, V. Larionov, I.A. Prior and W.C. Earnshaw. (2016). 3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin Mol. Cell. 64:790-802. PMID: 27840028; PMC4974353; DOI: 10.1016/j.molcel.2016.10.009; FREE ARTICLE
Molina O., G. Vargiu, M.A. Abad, A. Zhiteneva, J. Arulanandam, H. Masumoto, N. Kouprina, V. Larionov and W.C. Earnshaw. (2016) Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance. Nature Commun. 7:13334. PMID: 27841270; PMC5114538; DOI: 10.1038/ncomms13334. FREE ARTICLE
Ohta S., L.F. Montaño, F. de L. Alves., H. Ogawa, I. Toramoto, N. Sato, C.G. Morrison, S. Takeda, D.F. Hudson, J. Rappsilber and W.C. Earnshaw. (2016). Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes. Mol. Cell. Prot. 28:673-680. PMID: 27231315; PMC4974353; DOI: 10.1074/mcp.M116.057885; FREE ARTICLE
Ohzeki J., N.Shono, K. Otake, N.M.C. Martins, K. Kugou, H. Kimura, T. Nagase, V. Larionov, W.C. Earnshaw and H. Masumoto. (2016). KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation. Dev. Cell. 37:413-27. PMID: 27270040; PMC4906249; DOI: 10.1016/j.devcel.2016.05.006; FREE ARTICLE
Kim J.H., H.S. Lee, N.C. Lee, N.V. Goncharov, V. Kumeiko, H. Masumoto, W.C. Earnshaw, N. Kouprina, V. Larionov (2016). Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells. Oncotarget 7:14841-14856. PMID: 26943579; PMC4924756; DOI: 10.18632/oncotarget.7854; FREE ARTICLE
Wood, L, D.G. Booth, G. Vargiu, S. Ohta, F. deLima Alves, K. Samejima, T. Fukagawa, J. Rappsilber and W.C. Earnshaw. (2016). Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability. Open Biology 6: 150230. PMID: 26791246; PMC4736828; DOI: 10.1098/rsob.150230; FREE ARTICLE
Samejima I., M. Platani and W.C. Earnshaw (2015). Use of Mass Spectrometry to Study the Centromere and Kinetochore. Prog. Mol. Subcell. Biol. 56:3-27. PMID: 28840231; PMC4646952; DOI: 10.1007/978-3-319-58592-5_1. ARTICLE
Carmena, M., W.C. Earnshaw and D.M. Glover (2015). The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front. Cell Dev. Biol. 3: 73. PMID: 26636082; PMC4646952; DOI: 10.3389/fcell.2015.00073; FREE ARTICLE
Earnshaw, W.C. (2015). Q&A: William Earnshaw. Curr. Biol. 25: R483-R489. PMID: 26280061 DOI: 10.1016/j.cub.2015.03.003. FREE ARTICLE
Martins, N.M.C., J. Bergmann, N. Shono, H. Kimura, V.Larionov, H. Masumoto and W.C. Earnshaw. (2015). Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3. Mol. Biol. Cell. 27:177-196. PMID: 26564795; PMC4694756; DOI: 10.1091/mbc.E15-08-0605; FREE ARTICLE
Samejima, I. C. Spanos, F. de Lima Alves, T. Hori, M. Perpelescu, J. Zou, J. Rappsilber, T. Fukagawa and W.C. Earnshaw. (2015). Whole proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore. J. Cell Biol. 211:1141-1156. PMID: 26668330; PMC4687880; DOI: 10.1083/jcb.201508072. (featured in “In This Issue” – J. Cell Biol. 211:1098; and “Research Highlights” Nature Reviews Mol. Cell Biol. 17:66, 2016, doi:10.1038/nrm.2015.30) FREE ARTICLE
Shono, N., J. Ohzeki, K. Otake, N.M.C Martins, T. Nagase, H. Kimura, V. Larionov, W.C. Earnshaw, and H. Masumoto (2015). CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly. J. Cell Sci. 128: 4572-4587. PMID: 26527398; PMC4696500; DOI: 10.1242/jcs.180786; FREE ARTICLE
González-Loyola, A., G. Fernández-Miranda, M. Trakala, D. Partida, K. Samejima, H. Ogawa, M. Cañamero, A. de Martino, Á. Martínez-Ramírez, G. de Cárcer, I. Pérez de Castro, W.C. Earnshaw & M. Malumbres (2015). Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35: 3566-3578. PMID: 26240282; PMC4573715; DOI: 10.1128/MCB.01286-14; FREE ARTICLE
Samejima, K, M. Platani, M. Wolny, H. Ogawa, G. Vargiu, P.J. Knight, M. Peckham M & W.C. Earnshaw. (2015). The INCENP Coil is a Single Alpha Helical (SAH) Domain that Binds Directly to Microtubules and is Important for CPC Localization and Function in Mitosis. J. Biol. Chem. 290: 21460-21472. PMID: 26175154; PMC4571873; DOI: 10.1074/jbc.M115.645317; FREE ARTICLE
Platani, M., L. Trinkle-Mulcahy, M. Porter, A.A. Jeyaprakash and W.C. Earnshaw. (2015). Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J. Cell Biol. 210: 45-62. PMID: 26124292; PMC4494011; DOI: 10.1083/jcb.201410001; FREE ARTICLE
Papini, D., L. Langemeyer, M.A. Abad, A. Kerr, I. Samejima, P.A. Eyers, A.A. Jeyaprakash, J.M.G. Higgins, F.A. Barr and W.C. Earnshaw. (2015). TD-60 links RalA GTPase function to the CPC in mitosis. Nature Comms. 6: 7678. PMID: 26158537; PMC4510650; DOI:10.1038/ncomms8678; FREE ARTICLE
Earnshaw WC. (2015). Discovering centromere proteins: from cold white hands to the A, B, C of CENPs. Nat. Rev. Mol. Cell Biol. 16: 443-449. PMID: 25991376; DOI: 10.1038/nrm4001. ARTICLE
Kononenko, A., N.C.O. Lee, M. Liskovykh, H. Masumoto, W.C. Earnshaw, V. Larionov, N. Kouprina, (2014) Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette. Nucleic Acids Res. 43: e57. PMID: 25712097; PMC4482055; DOI: doi:10.1093/nar/gkv124; FREE ARTICLE
Carvalho A.X., H. Maiato, A. Maia, S. Ribeiro, P. Pontes, W. Bickmore, W.C. Earnshaw, and C. Sambade. (2015) Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase. PLoS One 10: e0124629. PMID: 25933052; PMC4416800; DOI: 10.1371/journal.pone.0124629; FREE ARTICLE
Ohta, S., L. Wood, I. Toramoto, K.-I. Yagyu, T. Fukagawa, and W.C. Earnshaw. (2015). CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly Mol. Biol. Cell 26:1225-1237. PMID: 25657325; PMC4454171; DOI: 10.1091/mbc.E14-09-1366; FREE ARTICLE
Barysz, H., J.H. Kim., Z.A. Chen, D.F. Hudson, J. Rappsilber, D.L. Gerloff and W.C. Earnshaw. (2015). 3D topology of the SMC2/SMC4 sub-complex from chicken condensin I revealed by cross-linking and molecular modeling. Open Biol. 5: 150005. PMID: 25716199; PMC4345284; DOI: 10.1098/rsob.150005; FREE ARTICLE
Ohzeki J, Larionov V, Earnshaw WC, Masumoto H. (2015). Genetic and epigenetic regulation of centromeres: a look at HAC formation. Chromosome Res. 23:87-103. PMID: 25682171; Identifier not found in PMC; DOI: 10.1007/s10577-015-9470-z. ARTICLE
Castonguay, E., S.A. White, A. Kagansky, D.J. St. Cyr, A.G. Castillo, C. Brugger, R. White, C. Bonilla, M. Spitzer, W.C. Earnshaw, T. Schalch, K. Ekwall, M. Tyers and R.C. Allshire. (2014). Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing. Mol. Cell. Biol. 15:662-674. PMID: 25487573; PMC4301722; DOI: 10.1128/MCB.01102-14; FREE ARTICLE
Kononenko, A.V., R. Bansal, N.C.O Lee, B.R. Grimes, H. Masumoto, W.C. Earnshaw, V. Larionov, N. Kouprina. (2014). A portable BRCA1-HAC module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. (2014). PMID: 25260588; PMC4245969; DOI: 10.1093/nar/gku870; FREE ARTICLE
Samejima K., H. Ogawa, A.V. Ageichik, K.L. Peterson, S.H. Kaufmann, M.T. Kanemaki and W.C. Earnshaw. (2014) A cell suicide module: Auxin-induced rapid degradation of Inhibitor of Caspase Activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation and cell death. J. Biol. Chem. 289: 31617-31623. PMID: 25248749; PMC4223357; DOI: 10.1074/jbc.M114.583542; (Faculty of 1000) FREE ARTICLE
Gohard, F.H., D. St-Cyr, M. Tyers and W.C. Earnshaw. (2014). Targeting the INCENP INbox: Aurora B interaction to inhibit CPC activity in vivo. Open Biol. 4: 140163. PMID: 25392451; PMC4248066; DOI: 10.1098/rsob.140163; FREE ARTICLE
Carmena, M., M.O. Lombardia, H. Ogawa and W.C. Earnshaw. (2014). Polo kinase regulates the localization and activity of the CPC in meiosis and mitosis in Drosophila melanogaster. Open Biol. 4:140162. PMID: 25376909; PMC4248065; DOI: 10.1098/rsob.140162; FREE ARTICLE
Erliandri, I., F. Haiqing, M. Nakano, J.-H. Kim, K.H. Miga, M. Liskovykh, W.C. Earnshaw, H. Masumoto, N. Kouprina, M.I. Aladjem, Vladimir Larionov. (2015). Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome. Nucleic Acids Res. 42:11502-11516. PMID: 25228468; PMC4191410; DOI: 10.1093/nar/gku835; FREE ARTICLE
Fukagawa, T. and W.C. Earnshaw. (2014). Quick Guide: Neocentromeres. Curr. Biol. 24:R946-R947. PMID: 25291631; DOI: 10.1016/j.cub.2014.08.032. FREE ARTICLE
Fukagawa, T. and W.C. Earnshaw. (2014). The centromere: Chromatin foundation for the kinetochore machinery. Dev. Cell 30:496-508. PMID: 25203206; PMC4160344; DOI: 10.1016/j.devcel.2014.08.016; FREE ARTICLE
Hori, T. 7, W.-H. Shang, 7, A. Toyoda, S. Misu, N. Monma, K. Ikeo, O. Molina, G. Vargiu, A. Fujiyama, Hi. Kimura, W.C. Earnshaw, and T. Fukagawa. (2014) Histone H4 Lys 20 mono-methylation of the CENP-A nucleosome is essential for kinetochore assembly. Dev. Cell 29:740-749. PMID: 24960696; PMC4081567; DOI: 10.1016/j.devcel.2014.05.001; FREE ARTICLE
Booth, D.G., M. Takagi, L. Sanchez-Pulido, E. Petfalski, G. Vargiu, K. Samejima, N. Imamoto, C.P. Ponting, D. Tollervey, W.C. Earnshaw† and P. Vagnarelli† (2014). Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. eLife 3:e01641. †equal corresponding authors. PMID: 24867636; PMC4032110; DOI: 10.7554/eLife.01641; FREE ARTICLE
Kouprina, N. A.N. Tomilin, H. Masumoto, W.C. Earnshaw, Vladimir Larionov. (2013). Human artificial chromosomes or HAC-based gene delivery vectors for biomedicine and biotechnology. Expert Opinion on Drug Delivery. 11:517-535. PMID: 24479793; DOI: 10.1517/17425247.2014.882314 ARTICLE
Ribeiro, S.A., P. Vagnarelli and W.C. Earnshaw. (2014) DNA content of a functioning chicken kinetochore. Chromosome Res. 22:7-13. PMID: 24633498; PMC4067537; DOI: 10.1007/s10577-014-9410-3; FREE ARTICLE
Earnshaw, W.C. (2013). Deducing protein function by forensic integrative cell biology. PLoS Biol. 11, e1001742 PMID: 24358025; PMC3866084; DOI: 10.1371/journal.pbio; FREE ARTICLE
Kim, J.H., T. Zhang, N.C. Wong, N. Davidson, J. Maksimovic, A. Oshlack, W.C. Earnshaw, P. Kalitsis & D.F. Hudson (2013). Condensin I associates with gene promoters, centromeres and telomeres in vertebrates. Nature Commun. 4:2537. PMID: 24088984; PMC4038772; DOI: 10.1038/ncomms3537; FREE ARTICLE
Lee, N.C.O., A. Kononenko, H.-S. Lee, E.N. Tolkunova, M.A. Liskovykh, H. Masumoto, W.C. Earnshaw, A.N. Tomilin, V. Larionov and N. Kouprina. (2013). Protecting a transgene expression from the HAC-based vector by different chromatin insulators. Cell Mol. Life Sci. 70:3723-3737. PMID: 23677492; PMC3771377; DOI: 10.1007/s00018-013-1362-9; FREE ARTICLE
Gohard, F.H., A.A. Zhiteneva, Alisa A & W.C. Earnshaw. (2014) Centromeres. In: eLS 2014, John Wiley & Sons Ltd: Chichester http://www.els.net/. DOI: 10.1002/9780470015902.a0005785.pub2 ARTICLE
Earnshaw, W.C. & D.W. Cleveland. (2013). CENP-A and the CENP Nomenclature: Response to Talbert and Henikoff. Trends Genet. 29:500-502. PMID: 223910159; DOI: 10.1016/j.tig.2013.06.008 ARTICLE
Lee, H.-S., N.C.O. Lee, B.R. Grimes, A. Samoshkin, A.V. Kononenko, H. Masumoto, W.C. Earnshaw, N. Kouprina and V. Larionov (2013). A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells. BMC Cancer, 13:252. PMID: 23694679; PMC3671967; DOI: 10.1186/1471-2407-13-252; FREE ARTICLE
Kononenko A.V., N.C. Lee, W.C. Earnshaw, N. Kouprina and V. Larionov. (2013). Re-engineering an alphoidtetO-HAC-based vector to enable high-throughput analyses of gene function. Nucleic Acids Res. 41:e107 PMID: 23558748; PMC3664798; DOI: 10.1093/nar/gkt205; FREE ARTICLE
Earnshaw, W.C., R.C. Allshire, B.E. Black, K. Bloom, B.R. Brinkley, W. Brown, I.M. Cheeseman, K.H.A. Choo, G.P. Copenhaver, J.G. DeLuca, A. Desai, S. Diekmann, S. Erhardt, M. Fitzgerald-Hayes, D. Foltz, T. Fukagawa, R. Gassmann, D.W. Gerlich, D.M. Glover, G.J. Gorbsky, S.C. Harrison, P. Heun, T. Hirota, L.E.T. Jansen, G. Karpen, G.J.P. Kops, M.A. Lampson, S.M. Lens, A. Losada, K. Luger, H. Maiato, P.S. Maddox, R.L. Margolis, H. Masumoto, A.D. McAinsh, B.G. Mellone, P. Meraldi, A. Musacchio, K. Oegema, R.J. O’Neill, E.D. Salmon, K. Scott, A.F. Straight, P.T. Stukenberg, B.A. Sullivan, K.F. Sullivan, C.E. Sunkel, J.R. Swedlow, C.E. Walczak, P.E. Warburton, S. Westermann, H.F. Willard, L. Wordeman, M. Yanagida, T.J. Yen, K. Yoda and D.W. Cleveland. (2013). Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant Chromosome Res. 21:101-106. PMID: 23580138; PMC3627038; DOI: 10.1007/s10577-013-9347-y FREE ARTICLE
Kouprina N., W.C. Earnshaw, H. Masumoto and V. Larionov. (2012) A new generation of human artificial chromosomes for functional genomics and gene therapy. Cellular and Molecular Life Sciences 70:1135-1148. PMID: 22907415; PMC3522797; DOI: 10.1007/s00018-012-1113-3; FREE ARTICLE
Shang W-H, T. Hori, N.M.C. Martins, A. Toyoda, S. Misu, N. Monma, I. Hiratani, K. Maeshima, K. Ikeo, A. Fujiyama, H. Kimura, W.C. Earnshaw and T. Fukagawa. (2013). Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev. Cell 24:635-648. PMID: 23499358; PMC3925796; DOI: 10.1016/j.devcel.2013.02.009; (Faculty of 1000) FREE ARTICLE
Tachiwana, H., Y. Miya, N. Shono, J. Ohzeki, A. Osakabe, K. Otake, V. Larionov., W.C. Earnshaw, H. Kimura, H. Masumoto, and H. Kurumizaka. (2013). Nap1 regulates proper CENP-B binding to nucleosomes Nucleic Acids Res. 41:2869-2880 PMID: 23325853; PMC3597661; DOI: 10.1093/nar/gks1464; FREE ARTICLE
Kouprina N., A. Samoshkin, I. Erliandri, M. Nakano, H.-S. Lee, H. Fu, M.I. Aladjem, H. Masumoto, W.C. Earnshaw and V. Larionov. (2012) Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere. ACS Synth. Biol. 1:590-601. PMID: 23411994; PMC3568986; DOI: 10.1021/sb3000436; ARTICLE
Carmena, M., M. Wheelock, H. Funabiki and W.C. Earnshaw. (2012). The Chromosomal Passenger Complex (CPC): From Easy Rider to the Godfather of Mitosis. Nature Revs. Mol. Cell Biol. 13:789-803. PMID: 23175282; PMC3729939; DOI: 10.1038/nrm3474; ARTICLE
Samejima, K., I. Samejima, P. Vagnarelli, H. Ogawa, G. Vargiu, D.A. Kelly, F. de Lima Alves, A. Kerr, L.C. Green, D.F. Hudson, S. Ohta, C.A. Cooke, C.J. Farr, J. Rappsilber, and W.C. Earnshaw. (2012). Mitotic chromosomes are compacted laterally by KIF4 and Condensin and axially by Topoisomerase IIα. J. Cell Biol.199:755-770. PMID: 23166350; PMC3514791; DOI: 10.1083/jcb.201202155 (featured in “In Focus” – J. Cell Biol. 199:715; and “Research Highlights” Nature Reviews Mol. Cell Biol. (2013) 14:2-4) (Faculty of 1000) FREE ARTICLE
Bergmann, J.H., N.M.C. Martins, V. Larionov, H. Masumoto & W.C. Earnshaw. (2012). HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res. 20:505-519. PMID: 22825423; DOI: 10.1007/s10577-012-9293-0 FREE ARTICLE
Ohzeki J., J.H. Bergmann, N. Kouprina, V.N. Noskov, M. Nakano, H. Kimura, W.C. Earnshaw, V. Larionov and H. Masumoto. (2012). Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. The EMBO J. 31:2391-2402. PMID: 22473132; PMC3364751; DOI: 10.1038/emboj.2012.82; FREE ARTICLE
Green L.C., P. Kalitsis, T.M. Chang, M. Cipetic, J.H. Kim, O. Marshall, L. Turnbull, C.B. Whitchurch, P. Vagnarelli, K. Samejima, W.C Earnshaw, K.H.A. Choo, D.F. Hudson. (2012). Contrasting roles of Condensin I and II in mitotic chromosome formation. J. Cell Sci. 125:1591-1604. PMID: 22344259; PMC3336382; DOI: 10.1242/jcs.097790 FREE ARTICLE
Vagnarelli, P. & W.C. Earnshaw. (2012) Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus 3:1-5. PMID: 22555598; PMC3383568; DOI: 10.4161/nucl.3.2.19267; FREE ARTICLE
Bergmann J.H., J. Jakubsche, N.M. Martins, A. Kagansky, M. Nakano, H. Kimura, D.A. Kelly, B.M. Turner, H. Masumoto, V. Larionov and W.C. Earnshaw. (2012). Epigenetic Engineering: Histone hyper-acetylation is compatible with kinetochore structure and function. J. Cell Sci. 125:411-421. PMID: 22331359; PMC3283876; DOI: 10.1242/jcs.090639 (featured in “In This Issue”: J. Cell Sci. 125:e202 issue) FREE ARTICLE
Carmena M., X. Pinson, M. Platani, Z. Salloum, Z. Xu, A. Clark, F. MacIsaac, H. Ogawa, U. Eggert, D.M. Glover, V. Archambault, W.C. Earnshaw. (2012). The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres. PLoS Biol. 10, e1001250 PMID: 22291575; PMC3265468; DOI: 10.1371/annotation/7832f573-e0d9-465f-b5d4-0ac1014b6112; FREE ARTICLE
Kim J.-H., A. Kononenko, I. Erliandri, T.-A. Kim, M. Nakano, Y. Iida, J. C. Barrett, M. Oshimura, H. Masumoto, W.C. Earnshaw, V. Larionov & N. Kouprina. (2011). Human Artificial Chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc. Nat. Acad. Sci. (USA) 108:20048-20053. PMID: 22123967; PMC3250132; DOI: 10.1073/pnas.1114483108; FREE ARTICLE
Flors C. and W.C. Earnshaw. (2011). Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr. Op. Chem. Biol. 15:838-844. PMID: 22098720; DOI: 10.1016/j.cbpa.2011.10.004 ARTICLE
Vagnarelli P., S. Ribeiro, L. Sennels, L. Sanchez-Pulido, F. de L. Alves, T. Verheyen, D.A. Kelly, C.P. Ponting, J. Rappsilber and W.C. Earnshaw. (2011). Repo-Man coordinates chromosomal reorganisation with nuclear envelope reassembly during mitotic exit. Dev. Cell 21: 328-342. PMID: 21820363; PMC3480639; DOI: 10.1016/j.devcel.2011.06.020 (featured in Nature Revs. Mol. Cell Biol. October issue) FREE ARTICLE
Bergmann J.H., M. Gomez Rodriguez, N.M.C. Martins, H. Kimura, D.A. Kelly, H. Masumoto, V. Larionov, L.E.T. Jansen and W.C. Earnshaw. (2011). Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. The EMBO J. 30: 328-340. PMID: 21157429; PMC3025471; DOI: 10.1038/emboj.2010.329 (see also EMBO J. 30:233-234) FREE ARTICLE
Ohta S., J.-C. Bukowski-Wills, L. Wood, F. de L. Alves, Z.A. Chen, J. Rappsilber and W.C. Earnshaw. (2010). Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1. Cold Spring Harbor Symp. Quant. Biol. 75:433-438 PMID: 21289047 ; DOI: 10.1101/sqb.2010.75.022 FREE ARTICLE
Ohta S., L. Wood, J.-C. Bukowski-Wills, J. Rappsilber and W.C. Earnshaw. (2010). Building mitotic chromosomes. Curr. Opin. Cell Biol. 23:114-121 PMID: 20974528; PMC3060342 DOI: 10.1016/j.ceb.2010.09.009; FREE ARTICLE
Fant X., K. Samejima, A. Carvalho, H. Ogawa, Z. Xu, Z. Yue, W.C. Earnshaw† and S. Ruchaud† (2010). Use of DT40 conditional knockout cell lines to study chromosomal passenger proteins function. Biochem. Soc. Trans. 38:1655-1659. †equal corresponding authors PMID: 21118143; PMC3428912; DOI: 10.1042/BST0381655 FREE ARTICLE
Xu Z, P. Vagnarelli, H. Ogawa, K. Samejima, W.C. Earnshaw. (2010) Gradient of increasing Aurora B activity is required for cells to execute mitosis. J. Biol. Chem. 285: 40163-40170. PMID: 20956539; PMC3000998; DOI: 10.1074/jbc.M110.181545; FREE ARTICLE
Iida Y., J.-H. Kim, Y. Kazuki, H. Hoshiya, M. Takiguchi, M. Hayashi, I. Erliandri, H.-S. Lee, A. Samoshkin, H. Masumoto, W.C. Earnshaw, N. Kouprina, V. Larionov and M. Oshimura. (2010). Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression. DNA Research 17: 293-301. PMID: 20798231; PMC2955713; DOI: 10.1093/dnares/dsq020; FREE ARTICLE
Ohta S.*, J.-C. Bukowski-Wills*, L. Sanchez-Pulido, F. de L. Alves, L. Wood, Z.A. Chen, M. Platani, L. Fischer, D.F. Hudson, C.P. Ponting, T. Fukagawa, W.C. Earnshaw† and J. Rappsilber†. (2010). The protein composition of mitotic chromosomes determined using multi-classifier combinatorial proteomics. Cell 142: 810-821. *equal first authors. †equal corresponding authors. PMID: 20813266; PMC2982257; DOI: 10.1016/j.cell.2010.07.047 (Faculty of 1000; see also Dev. Cell 19: 356-359; Nature Methods 7: 869; Biotechniques – http://www.biotechniques.com/news/biotechniquesNews/biotechniques-303722.html Science Daily – http://www.sciencedaily.com/releases/2010/09/100902121055.htm) FREE ARTICLE
Fernández-Miranda, I. Pérez de Castro, M. Carmena, C. Aguirre-Portolés, S. Ruchaud, X. Fant, G. Montoya, W.C. Earnshaw and M. Malumbres. (2010). SUMOylation modulates the function of Aurora-B kinase. J. Cell. Sci. 123: 2823-2833. PMID: 20663916; PMC2915883; DOI: 10.1242/jcs.065565; FREE ARTICLE
Patzlaff J.S., E. Terrenoire, B.M. Turner, W.C. Earnshaw and J.R. Paulson. (2010). Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp. Cell Res. 316: 2123-2135. PMID: 20452346; PMC2938188; DOI: 10.1016/j.yexcr.2010.05.003; FREE ARTICLE
Ribeiro, S.A., P. Vagnarelli, Y. Dong, T. Hori, B.F. McEwen, T. Fukagawa, C. Flors and W.C. Earnshaw. (2010). A super-resolution map of the vertebrate kinetochore. Proc. Nat. Acad. Sci. (USA) 107: 10484-10489. PMID: 20483991; PMC2890832; DOI: 10.1073/pnas.1002325107; FREE ARTICLE
Mocciaro, A., E. Berdougo, E. Black, P. Vagnarelli, W.C. Earnshaw, D. Gillespie, P. Jallepalli, and E. Schiebel. (2010). Vertebrate cells deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J. Cell Biol. 189: 631-639. PMID: 20479464; PMC2872905; DOI: 10.1083/jcb.200910057 (Faculty of 1000) FREE ACCESS